Research. My research investigates how the endocannabinoid system gates the stress response. Specifically, I am investigating how both tonic and phasic endocannabinoid signalling regulate stress-responsivity by measuring HPA axis activation and self-directed grooming behaviors. I am harnessing a wide range of techniques to answer these questions: pharmacology, optogenetics, fiber photometry and immunohistochemistry.
Hobbies. My recreational passions include mountain biking, skiing and having a pint with my buddies.
Favourite paper. Favorite paper: “Nongenomic Glucocorticoid Inhibition via Endocannabinoid Release in the Hypothalamus: A Fast Feedback Mechanism” (Di et al., 2003; PubMed link). This is the first paper to suggest a role for endocannabinoids in the stress response by showing the necessity of cannabinoid signalling during glucocorticoid negative feedback in the PVN.
Endocannabinoids, cannabinoids and the regulation of anxiety
Petrie GN, Nastase AS, Aukema RJ, Hill MN (2021)
Oleoyl glycine: interference with the aversive effects of acute naloxone-precipitated MWD, but not morphine reward, in male Sprague-Dawley rat
Petrie GN, Wills KL, Piscitelli F, Smoum R, Limebeer CL, Rock EM, Humphrey AE, Sheppard-Perkins M, Lichtman AH, Mechoulam R, Di Marzo V, Parker LA
Psychopharmacology (Berlin), 236(9):2623-2633
Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice.
Mock ED, Mustafa M, Gunduz-Cinar O, Cinar R, Petrie GN, Kantae V, Di X, Ogasawara D, Varga Z, Paloczi J, Miliano C, Donvito G, van Esbroeck ACM, van der Gracht AMF, Kotsogianni L, Park JK, Martella A, van der Wel T, Soethoudt M, Jiang M, Wendel TJ, Janssen APA, Bakker AT, Donovan CM, Castillo LI, Florea BI, Wat J, van den Hurk H, Wittwer M, Grether U, Holmes A, van Boeckel CAA, Hankemeier T, Cravatt BF, Buczynski MW, Hill MN, Pacher P, Lichtman AH, van der Stelt M (2020)
Nature Chemical Biology 16(6):667-675
Full list of publications
I earned my Undergraduate degree in psychology at the University of Guelph (B.A. 2016). My passion for cannabinoids began while completing an honors thesis in Linda Parker’s lab on how the endogenous cannabinoid, Oleoyl Glycine, can be used to treat morphine withdrawal.