DR. MATTHEW HILL
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Research. My research career has largely focused on the intersection between cannabinoids and the stress response. My lab has 3 primary research streams, all of which are independently funded, which focus on 1) stress and endocannabinoids; 2) cannabinoid regulation of feeding and metabolism; 3) the neurodevelopmental and behavioural impacts of cannabis exposure.
Hobbies. Personally, I love to cook and travel and am an avid dog fan, especially those of the bulldog breed. I like to ski and hike in the rocky mountains nearby.
Favourite paper. I am going to select 3 papers, as there were 3 key papers that got the entire field of stress, affective behaviour and endocannabinoids rolling:
1) Marsicano et al. (2002). The Endogenous Cannabinoid System Controls Extinction of Aversive Memories. Nature, 418(6897): 530-534. 2) Di et al. (2003). Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism. Journal of Neuroscience, 23(12): 4850-4857. 3) Patel et al. (2004). Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis. Endocrinology, 145(12): 5431-5438. Publications
SELECT PUBLICATIONS Yasmin F, Colangeli R, Morena M, Filipski S, Pittman QJ, van der Stelt M, Hillard CJ, Teskey GC, McEwen BS, Hill MN*, Chattarji S*. (2020). Stress-induced Modulation of Endocannabinoid Signaling Leads to Delayed Strengthening of Synaptic Connectivity in the Amygdala. Proceeding of the National Academy of Sciences USA, 117(1), 650-655. * = co-senior authorship Morena M, Patel S, Bains JS, Hill MN. (2016). Neurobiological Interactions Between Stress and the Endocannabinoid System. Neuropsychopharmacology, 41(1), 80-102 Gray JM, Vecchiarelli HA, Morena M, Lee TT, Hermanson D, Kim AB, McLaughlin RJ, Hassan K, Kuhne C, Wotjak CT, Deussing JM, Patel S, Hill MN. (2015). Corticotropin Releasing Hormone Drives Anandamide Hydrolysis in the Amygdala to Promote Anxiety. Journal of Neuroscience, 35(9), 3879-3892 FULL LIST OF PUBLICATIONS Awards
education
Education. I began working in the laboratory of Dr. Boris Gorzalka as a 2nd year undergraduate in 1999. My initial projects were at looking at the behavioural effects of the hormones corticosterone and melatonin on stress coping behaviour. I continued graduate work in the Gorzalka lab where I transitioned into exploring the endocannabinoid system, how it interacts with stress hormones and how these changes contribute to alterations in affective and cognitive behaviour. The focus of my thesis was examining the impacts of chronic stress and antidepressant treatments on the endocannabinoid system. I also spent a large portion of my graduate training in two other labs, those of Dr. Cecilia Hillard and Dr. Victor Viau, where I honed skills in the neuropharmacology of cannabinoids and the psychoneuroendocrinology of stress, respectively. In 2008, I finished my PhD and left UBC to join the laboratory of Dr. Bruce McEwen at Rockefeller University in New York City. I finished my postdoctoral fellowship and started my own lab at the University of Calgary in the summer of 2011. |