DR. MATTHEW HILL
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Research. My research career has largely focused on the intersection between cannabinoids and the stress response. My lab has 3 primary research streams, all of which are independently funded, which focus on 1) stress and endocannabinoids; 2) cannabinoid regulation of feeding and metabolism; 3) the neurodevelopmental and behavioral impacts of cannabis exposure
Hobbies Personally, I love to cook and travel and am an avid dog fan, especially those of the bulldog breed. I like to ski and hike in the rocky mountains nearby
Favourite paper. I am going to select 3 papers, as there were 3 key papers that got the entire field of stress, affective behavior and endocannabinoids rolling:
(1) The Endogenous Cannabinoid System Controls Extinction of Aversive Memories. Marsicano et al, 2002. Nature 418(6897): 530-4. 2) Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism. Di et al, 2003. J Neurosci. 23(12): 4850-7. 3) Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis. Patel et al, 2004. Endocrinology 145(12): 5431-8. Publications
SELECT PUBLICATIONS
Stress-induced Modulation of Endocannabinoid Signaling Leads to Delayed Strengthening of Synaptic Connectivity in the Amygdala. Yasmin F, Colangeli R, Morena M, Filipski S, Pittman QJ, van der Stelt M, Hillard CJ, Teskey GC, McEwen BS, Hill MN*, Chattarji S*. (2020) Proceeding of the National Academy of Sciences USA 117(1), 650-655. * = co-senior authorship LINK Neurobiological Interactions Between Stress and the Endocannabinoid System Morena M, Patel S, Bains JS, Hill MN (2016) Neuropsychopharmacology 41(1), 80-102 LINK Corticotropin Releasing Hormone Drives Anandamide Hydrolysis in the Amygdala to Promote Anxiety. Gray JM, Vecchiarelli HA, Morena M, Lee TT, Hermanson D, Kim AB, McLaughlin RJ, Hassan K, Kuhne C, Wotjak CT, Deussing JM, Patel S, Hill MN (2015) Journal of Neuroscience 35(9), 3879-3892 LINK Full list of publications Research Interests. Awards
education
Education. I began working in the laboratory of Dr. Boris Gorzalka as a 2nd year undergraduate in 1999. My initial projects were at looking at the behavioural effects of the hormones corticosterone and melatonin on stress coping behaviour. I continued graduate work in the Gorzalka lab where I transitioned into exploring the endocannabinoid system, how it interacts with stress hormones and how these changes contribute to alterations in affective and cognitive behaviour. The focus of my thesis was examining the impacts of chronic stress and antidepressant treatments on the endocannabinoid system. I also spent a large portion of my graduate training in two other labs, those of Dr. Cecilia Hillard and Dr. Victor Viau, where I honed skills in the neuropharmacology of cannabinoids and the psychoneuroendocrinology of stress, respectively. In 2008, I finished my PhD and left UBC to join the laboratory of Dr. Bruce McEwen at Rockefeller University in New York City. I finished my postdoctoral fellowship and started my own lab at the University of Calgary in the summer of 2011. |
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Research funded by Brain Canada, BONF, CFI, CIHR, NIH and NSERC. Many thanks to the University of Calgary Cumming School of Medicine, Hotchkiss Brain Institute, Mathison Centre, and Alberta Children's Hospital for their support.
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